Granuloma annulare (GA) is a benign skin condition that may affect all ages. The cause for granuloma annulare is unknown, and several types exist, from single skin spots to more generalized cases involving much of the skin. Granuloma annulare typically appears as skin-colored to red-purple bumps usually on the hands, fingers, feet, knees, or low back. A generalized form may cause skin lesions to appear all over the body. GA may not cause any symptoms, or it may burn or be extremely itchy. Some cases of granuloma annulare in women have been associated with thyroid disease called autoimmune thyroiditis. Most cases of GA resolve spontaneously without treatment. A skin biopsy leads to confirmation of the diagnosis of granuloma annulare and sometimes causes spontaneous cure. Topical steroids, light therapy, and oral prescription medications have been tried in widespread cases of granuloma annulare.