Plasma Rich Fibrin (PRF) and EZgel are two innovative cosmetic procedures offered by Art of Skin MD in north county San Diego. Here are some commonly asked questions about these procedures.

What is Plasma Rich Fibrin (PRF)?

Plasma Rich Fibrin (PRF) is a natural substance derived from a patient’s own blood. PRF is obtained by taking a small amount of the patient’s blood and placing it in a centrifuge machine that separates the blood cells and plasma. The plasma is then collected and used for cosmetic procedures. PRF contains a high concentration of platelets, growth factors, and white blood cells, which are important for the body’s natural healing process.  It can be injected directly into the skin or mixed with other substances such as hyaluronic acid to enhance its effects.

How is PRF used in cosmetic procedures?

PRF is an increasingly popular cosmetic treatment that offer a range of benefits for various aesthetic concerns. PRF is commonly used in cosmetic procedures such as facials, microneedling, and hair restoration.  Here are some of the most common and unique applications of PRF in cosmetic procedures:

• Facial rejuvenation: PRF can be used to improve skin tone and texture, reduce the appearance of fine lines and wrinkles, and promote overall skin health.
• Scar revision and acne scarring: PRF can help reduce the appearance of scars from acne, injury, or surgery.
• Hair restoration: PRF can stimulate hair growth and improve the thickness and density of hair in areas of hair loss or thinning.
• Lip enhancement: PRF can be used to enhance the shape, volume, and definition of the lips.
• Hand rejuvenation: PRF can improve the appearance of aging hands by reducing the visibility of veins and tendons and improving skin quality.

It’s important to note that while PRF and EZ gel are effective treatments for a variety of cosmetic concerns, the best treatment option for each patient will depend on their individual goals, anatomy, and medical history. Patients should consult with a qualified medical professional to determine the most appropriate treatment plan for their needs.

What are the benefits of using PRF in cosmetic procedures?

• PRF promotes collagen production, which can improve skin texture and reduce fine lines and wrinkles.
• It can also improve skin hydration and elasticity.
• PRF can enhance the results of other cosmetic procedures and reduce recovery time.
• It may serve as an alternate cosmetic injectable procedure for patients that have a contraindication or would like an alternative to traditional injectable fillers.

What is the PRF procedure like?

The PRF procedure starts with a small amount of blood being drawn from the patient. The blood is then placed in a centrifuge machine, which separates the blood cells and plasma. The plasma is collected and used for the procedure. The PRF is then injected into the treatment area using a cannula or fine needle.

Can you run me through step by step how the PRF procedure is completed?

• • 1. The patient’s blood is drawn.
    2. The blood is placed in a centrifuge machine.
    3. The machine separates the blood cells and plasma.
    4. The plasma is collected and used for the procedure.
    5. The PRF is injected into the treatment area using a fine needle.

What is EZgel?

• EZgel is a dermal filler that contains PRF (platelet rich fibrin).
• It is used to add volume and contour to areas such as the cheeks, lips, and under-eye area.

How does EZgel work?

• EZgel works by adding volume to the skin and stimulating collagen production.
• The PRF in EZgel contains growth factors that promote tissue regeneration and healing.

How is EZgel used in cosmetic procedures?

EZgel is a versatile cosmetic treatment that can be used in a variety of ways to improve the appearance of the face and other areas of the body. Here are some of the common and lesser used but unique ways EZgel is employed in cosmetic procedures:

• Dermal filler: EZgel is most commonly used as a dermal filler to plump up the skin and fill in wrinkles and fine lines. It can be used to treat a variety of areas, including the cheeks, lips, nasolabial folds (smile lines), marionette lines (lines around the mouth), and chin.
• Periocular rejuvenation (undereye and brow volume loss): EZ gel can be used to replenish lost volume the undereye region to help correct undereye circles, tear troughs and thinning skin.   EZgel can also be injected in the brow region to rejuvenate the upper eyelid zone.
• Facial contouring: EZ gel can be used to enhance or contour the cheekbones, jawline, and chin for a more sculpted facial appearance.
• Non-surgical rhinoplasty: EZgel can be used to reshape the nose, correct asymmetry, and improve the appearance of bumps or dips in the bridge of the nose. This is a less common use of EZgel.
• Chin augmentation: EZgel can be used to enhance the chin and improve the overall balance of the face. This is a less common use of EZgel.
• Jawline enhancement: EZgel can be used to create a more defined jawline and improve the overall contour of the face. This is a less common use of EZgel.
• Hand rejuvenation: EZgel can be used to restore lost volume in the hands and improve the appearance of veins and tendons. This is a less common use of EZgel.
• Earlobe rejuvenation: EZgel can be used to plump up sagging or wrinkled earlobes and improve the appearance of earlobe piercings. This is a rare use of EZgel.

Overall, EZgel is a safe and effective treatment that can be customized to each patient’s individual needs and goals. Patients should consult with a qualified medical professional at Art of Skin MD to determine if EZgel is the right treatment option for their needs.

What are the benefits of using EZgel?

• EZgel provides immediate results and can last for up to 12 months.
• It is a natural-looking filler that enhances the contours of the face without looking artificial.
• EZgel can be used in combination with other cosmetic procedures to achieve a more comprehensive rejuvenation.

Who is a good candidate for PRF or EZgel?

PRF and EZgel are suitable for patients who want to improve the appearance of their skin or restore lost volume in certain areas of the face. Good candidates for PRF or EZgel should be in good overall health and have realistic expectations for the outcome of the procedure.

Can PRF and EZgel be combined with other procedures?

Yes, PRF and EZgel can be combined with other cosmetic procedures such as Botox, dermal fillers, or laser resurfacing to achieve a more comprehensive rejuvenation.

Is PRF FDA-approved or cleared and for what?

PRF is not currently FDA-approved or cleared for cosmetic purposes. However, it is considered a safe and effective procedure when performed by a qualified medical professional.

How many treatments are required for PRF or EZ gel?

The number of treatments required for PRF or EZgel will depend on the individual patient’s needs and goals. Some patients may see results after a single treatment, while others may require multiple sessions to achieve their desired outcome.

How does PRF differ from PRP?

PRF and PRP are both derived from the patient’s own blood and contain growth factors that promote tissue regeneration and healing. However, PRF contains a higher concentration of platelets and white blood cells than PRP, which makes it a more potent and effective treatment.

The release of growth factors occurs more slowly with PRF than PRP.  The release of growth factors with PRP occurs for a few hours after injection, while PRF allows a longer and slower release of growth factors into the injected tissues for up to a week or longer.   PRF contains mesenchymal cells (multipotent stem cells) that can promote the regeneration of healthy tissues.  PRP does not contain mesenchymal cells and has fewer cells and no fibrin matrix to support slower growth factor release.

How long has PRF procedures been conducted?

PRF procedures have been conducted for over 10 years and have been shown to be a safe and effective treatment for a variety of cosmetic concerns. Some of its first applications were in oral maxillofacial & orthopedic surgery as a use of injectable stem cell therapy and to regenerate tissues.

Can PRF be used instead of PRP for hair loss?

PRF can be used as an alternative to PRP for hair loss treatment. PRF has been shown to be effective in promoting hair growth and improving hair density.

Men experiencing hair loss or thinning may benefit from PRF and EZgel treatments offered at Art of Skin MD. PRF injections can stimulate hair follicles, promoting new hair growth and thickening existing hair. EZgel injections can also be used for hair restoration by promoting collagen production and enhancing blood flow to the scalp.

Can PRF be used in microneedling?

Yes, PRF can be used in conjunction with microneedling treatments to improve the overall results of the procedure. This combination is known as PRF microneedling, and it involves using a microneedling device to create small punctures in the skin’s surface and then applying PRF directly to the treated area.

The PRF helps to promote healing and stimulate collagen production in the skin, which can enhance the benefits of microneedling. PRF microneedling is often used to address concerns such as fine lines, wrinkles, acne scars, and uneven skin tone and texture.

It is important to note that PRF microneedling should only be performed by a qualified healthcare provider who has experience with this technique. They can help to determine if this treatment is right for you and develop a customized treatment plan to achieve your desired results.

Does the PRF or EZgel injection hurt?

PRF and EZgel injections are generally well-tolerated by most patients and are not considered to be very painful. As PRF and EZgel does not contain calcium gluconate, calcium chloride or other additives in processing, it tends to be less painful that PRP treatments.  However, like with any injection, some patients may experience mild discomfort or a slight burning or stinging sensation during the injection.

To minimize discomfort, your healthcare provider may apply a topical numbing cream to the treatment area before the injection. Additionally, both PRF and EZgel contain natural pain-relieving and anti-inflammatory agents, which can help to reduce any pain or discomfort during the procedure.

If you are concerned about pain or discomfort during PRF or EZgel injections, it is important to discuss your concerns with your healthcare provider at Art of Skin MD. They may be able to suggest additional strategies to minimize any discomfort, such as using ice or a local anesthetic.

Can I have an allergy to PRF?

Since PRF is derived from the patient’s own blood, the risk of an allergic reaction is low. However, patients with a history of blood disorders or autoimmune diseases should consult with their doctor before undergoing PRF treatment.

Are there any adverse events or complications from PRF or EZgel?

PRF and EZ gel treatments are generally considered safe, minimally invasive, and well-tolerated by most patients. However, as with any medical procedure, there are potential risks and complications that patients should be aware of before undergoing treatment. Here are some of the possible complications or adverse events that may occur with PRF or EZ gel treatments:

• Pain, bruising, or swelling at the injection site
• Infection at the injection site
• Bleeding or hematoma formation
• Allergic reactions to the PRF or EZ gel components
• Unsatisfactory results or asymmetry
• Nerve damage or injury
• Skin discoloration or changes in skin texture
• Rarely, embolism or blockage of a blood vessel

To minimize the risk of complications, it is important to choose a qualified and experienced medical professional to perform the treatment, and to follow all pre- and post-treatment instructions carefully. Patients should also disclose any medical conditions or medications they are taking before undergoing treatment. If any complications or adverse events occur, patients should seek medical attention immediately.

Who is a poor candidate for PRF or EZgel?

While PRF and EZgel are generally safe and effective treatments for many people, there are some individuals who may not be good candidates for these procedures. Here are some factors that may make a person a poor candidate for PRF or EZgel:

• Blood disorders: Individuals with blood disorders or who are taking blood thinning medication may not be good candidates for PRF or EZgel, as these treatments involve drawing blood and injecting it back into the body.
• Active infections or inflammation: PRF and EZgel treatments should not be performed on areas of the body that are actively infected or inflamed, as this can increase the risk of complications.
• Pregnancy or breastfeeding: While there is no evidence to suggest that PRF or EZgel is unsafe for pregnant or breastfeeding women, it is generally recommended that these individuals avoid cosmetic procedures until after they have finished breastfeeding.
• Allergies: Individuals who have a history of allergies or allergic reactions may be at increased risk of complications from PRF or EZgel. It is important to inform your healthcare provider of any allergies you may have before undergoing these treatments.
• Unrealistic expectations: PRF and EZgel can produce significant improvements in the appearance of the skin, but they are not a “miracle cure” for all skin concerns. Patients with unrealistic expectations may be disappointed with the results of these treatments.

It is important to discuss your medical history and individual needs with a qualified healthcare provider at Art of Skin MD before undergoing PRF or EZgel to determine if these treatments are right for you.

Is PRF a replacement for injectable dermal fillers such as Restylane or Juvederm?

PRF is not a replacement for injectable dermal fillers such as hyaluronic acid fillers like Restylane or Juvederm. While PRF can help stimulate collagen production and improve skin texture, it does not provide the same immediate and significant volume enhancement as dermal fillers. PRF and dermal fillers can be used together to achieve a more comprehensive rejuvenation. The choice of treatment will depend on the individual patient’s needs and goals, and a qualified medical professional can help determine the best course of action.

Can PRF be mixed with collagen stimulating products like Sculptra (poly-L-lactic acid) or Radiesse (calcium hydroxylapatite)?  Is it safe?

There is limited information on the safety and efficacy of combining PRF with collagen-stimulating products like Sculptra (poly-L-lactic acid) or Radiesse (calcium hydroxylapatite). While it is theoretically possible to combine these treatments, there are potential risks and uncertainties that should be considered.

The FDA has not approved or cleared PRF for cosmetic purposes, and there are currently no guidelines or regulations in place regarding its use in combination with other treatments. Therefore, the combination of PRF with other treatments is considered off-label use.

As with any off-label use of medical treatments, the combination of PRF with other treatments should only be performed by a qualified medical professional who has experience and expertise in the use of these treatments. The medical professional should also carefully consider the potential risks and benefits of the combination treatment, and discuss these with the patient before proceeding.

What is the approximate cost of PRF or EZgel?

The cost of PRF and EZ gel treatments can vary depending on several factors such as the location of the clinic, the expertise of the medical professional performing the treatment, the number of sessions required, and the extent of the treatment area. In general, the cost of PRF and EZ gel treatments can range from a hundreds of dollars to several thousand dollars per session.

It’s important to note that PRF and EZ gel treatments are considered elective cosmetic procedures and are not covered by insurance. Patients should discuss the costs of the treatments with their medical professional at Art of Skin MD and inquire about any financing or payment plan options that may be available.

At Art of Skin MD, we offer PRF and EZgel as part of our comprehensive range of cosmetic procedures. Our experienced team of professionals will work with you to develop a personalized treatment plan that addresses your unique needs and goals. Contact us today at 858.792.7546 to schedule a consultation and learn more about how PRF and EZgel can enhance your natural beauty.